Small businesses will bear a significant burden under Obamacare. New regulations, mandates, taxes and numerous costs will impact how companies operate.

The National Federation of Independent Business counted all of these new requirements and came up with 25 ways the new health care law changes life for business owners over the next 10 years. Its video puts some perspective on what’s to come in the years ahead.

Earlier this week Heritage’s John Ligon revealed four ways Obamacare penalizes small businesses: higher health care costs, an ineffective small business tax credit, higher regulation compliance costs, and Medicare taxes on “flow-through” and investment income.

Medium-sized businesses between 50 and 199 employees don’t escape Obamacare’s taxes either. Ligon estimates that employees will ultimately pay the biggest price with lower wages, discontinued hiring or even loss of employment.